Prevention/Detection / Your Questions Click a letter to see a list of topics beginning with that letter ABCDEFGHIJKLMNOPQRSTUVWXYZ Sexuality and Vaginal Dryness I am using Estrace cream for vaginal dryness. Will it have an effect on my partner? It is recommended that you do not use Estrace vaginal cream right before or even several hours before having intercourse or other types of vaginal penetration. However, the dose of estrogen in Estrace is very low, and not much is absorbed, so even if you did on occasion have sex within a few hours of using the cream it should not have an effect on your partner. (There have been a few anecdotal reports of men developing gynecomastia (enlarged breasts) from frequent exposure to their partner's estrogen vaginal cream.)
In terms of oral sex: Swallowed cream needs to be digested and metabolized so it would probably be okay to assume that even a lower dose would be absorbed and would not affect your partner—but no one has studied that!
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